Author: Mei, Han; Kosakovsky Pond, Sergei; Nekrutenko, Anton
Title: Stepwise Evolution and Exceptional Conservation of ORF1a/b Overlap in Coronaviruses Cord-id: wjg98wnt Document date: 2021_9_10
ID: wjg98wnt
Snippet: The programmed frameshift element (PFE) rerouting translation from ORF1a to ORF1b is essential for propagation of coronaviruses. The overlap between the two reading frames, a slippery sequence, and an ensemble of secondary structure elements places severe constraints on this region as most possible nucleotide substitution may disrupt one or more of these features. Here we performed a comparative analysis of all available coronaviral genomic data available to date to demonstrate exceptional conse
Document: The programmed frameshift element (PFE) rerouting translation from ORF1a to ORF1b is essential for propagation of coronaviruses. The overlap between the two reading frames, a slippery sequence, and an ensemble of secondary structure elements places severe constraints on this region as most possible nucleotide substitution may disrupt one or more of these features. Here we performed a comparative analysis of all available coronaviral genomic data available to date to demonstrate exceptional conservation and detect signatures of selection within the PFE region.
Search related documents:
Co phrase search for related documents- loop region and low frequency: 1
Co phrase search for related documents, hyperlinks ordered by date