DimachkieSpectrum of Acute Neuropathy Associated with Covid-19: Clinical and electrophysiological study of 13 patients from a single center

Yaranagula, Sai Deepak; Koduri, Venkata Krishna Chaitanya

OBJECTIVES: To analyze clinical and nerve conduction patterns in patients with acute neuropathy, preceded by or concomitantly having Covid-19 disease (Acute Neuropathy Associated with Covid-19 or ANAC 19). METHODS: Retrospective analysis of clinical details, laboratory evaluation and electrophysiological parameters in patients with ANAC 19was done. This data was compared with non Covid GBS described in literature and also with patients of acute neuropathy without Covid 19 who had presented to our center during the period of study. RESULTS: Records of thirteen patients with ANAC 19were reviewed. Most patients clinically had paraparesis, and electrophysiologically showed demyelinating neuropathy. Peroneal and Sural nerves were the most frequently abnormal motor and sensory nerves respectively. A proportion of patients showed a peroneal velocity sparing pattern. Higher incidence of paraparesis and encephalopathy differentiated ANAC 19from non Covid GBS. CONCLUSIONS: ANAC 19has a comparable electrophysiological profile to non Covid GBS. However, it has a distinct clinical presentation.