Time course prevalence of post-COVID pain symptoms of musculoskeletal origin in patients who had survived to SARS-CoV-2 infection: a systematic review and meta-analysis

Fernández-de-Las-Peñas, César; Navarro-Santana, Marcos; Plaza-Manzano, Gustavo; Palacios-Ceña, Domingo; Arendt-Nielsen, Lars

ABSTRACT: The aim of this review/meta-analysis is to synthesize the prevalence of post-COVID pain symptoms of musculoskeletal origin in hospitalized/non-hospitalized patients recovered from SARS-CoV-2 infection. MEDLINE, CINAHL, PubMed, EMBASE, and Web of Science databases, as well as medRxiv and bioRxiv preprint servers were searched up to May 1, 2021. Studies or preprints reporting data on post-COVID pain symptoms such as myalgias, arthralgias, or chest pain after SARS-CoV-2 infection and collected by personal, telephonic, or electronical interview were included. The methodological quality of the studies was assessed using the Newcastle-Ottawa Scale. Random-effects models were used for meta-analytical pooled prevalence of each post-COVID musculoskeletal pain symptom. Data synthesis was categorized at onset or hospital admission, and at 30, 60, and 90, and ≥180 days after. From a total of 12,123 studies identified, 27 peer-reviewed studies and 6 preprints were included. The sample included 14,639 hospitalized and 11,070 non-hospitalized COVID-19 patients. The methodological quality of almost 70% studies was fair. The overall prevalence of post-COVID myalgia, joint pain, and chest pain ranged from 5.65% to 18.15%, 4.6% to 12.1%, and 7.8% to 23.6% respectively at different follow-up periods during the first year post-infection. Time trend analysis showed a decrease prevalence of musculoskeletal post-COVID pain from the symptom's onset to 30 days after, an increase 60 days after, but with a second decrease ≥180 days after. This meta-analysis has shown that almost 10% of individuals infected by SARS-CoV-2 will suffer from musculoskeletal post-COVID pain symptomatology at some time during the first year after the infection.