Selected article for: "Î promoter and immune response"
Author: Zhou, Zhihai; Sun, Yuan; Yan, Xiaoling; Tang, Xiaoyu; Li, Qianniu; Tan, Yaorong; Lan, Tian; Ma, Jingyun
Title: Swine acute diarrhea syndrome coronavirus (SADS-CoV) antagonizes interferon-β production via blocking IPS-1 and RIG-I
  • Cord-id: xb057vzv
  • Document date: 2019_12_26
    • ID: xb057vzv
    Snippet: Swine acute diarrhea syndrome coronavirus (SADS-CoV), a newly emerging enteric coronavirus, is considered to be associated with swine acute diarrhea syndrome (SADS) which has caused significantly economic losses to the porcine industry. Interactions between SADS-CoV and the host innate immune response is unclear yet. In this study, we used IPEC-J2 cells as a model to explore potential evasion strategies employed by SADS-CoV. Our results showed that SADS-CoV infection failed to induce IFN-β prod
    Document: Swine acute diarrhea syndrome coronavirus (SADS-CoV), a newly emerging enteric coronavirus, is considered to be associated with swine acute diarrhea syndrome (SADS) which has caused significantly economic losses to the porcine industry. Interactions between SADS-CoV and the host innate immune response is unclear yet. In this study, we used IPEC-J2 cells as a model to explore potential evasion strategies employed by SADS-CoV. Our results showed that SADS-CoV infection failed to induce IFN-β production, and inhibited poly (I:C) and Sendai virus (SeV)-triggered IFN-β expression. SADS-CoV also blocked poly (I:C)-induced phosphorylation and nuclear translocation of IRF-3 and NF-κB. Furthermore, SADS-CoV did not interfere with the activity of IFN-β promoter stimulated by IRF3, TBK1 and IKKε, but counteracted its activation induced by IPS-1 and RIG-I. Collectively, this study is the first investigation that shows interactions between SADS-CoV and the host innate immunity, which provides information of the molecular mechanisms underlying SASD-CoV infection.

    Search related documents:
    Co phrase search for related documents
    • accession number and acid inducible gene: 1
    • accession number and acute sars cov respiratory syndrome coronavirus: 1, 2, 3
    • accession number and luciferase reporter: 1
    • accession number and luciferase reporter plasmid: 1
    • accessory protein and acid inducible: 1
    • accessory protein and acid inducible gene: 1
    • accessory protein and acute diarrhea: 1
    • accessory protein and acute sars cov respiratory syndrome coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acid inducible and acute sars cov respiratory syndrome coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
    • acid inducible and luciferase reporter: 1, 2
    • acid inducible gene and acute sars cov respiratory syndrome coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
    • acid inducible gene and luciferase reporter: 1, 2
    • activation interfere and acute sars cov respiratory syndrome coronavirus: 1
    • acute diarrhea and luciferase activity: 1
    • acute sars cov respiratory syndrome coronavirus and luciferase activity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
    • acute sars cov respiratory syndrome coronavirus and luciferase reporter: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
    • acute sars cov respiratory syndrome coronavirus and luciferase reporter plasmid: 1
    • acute sars cov respiratory syndrome coronavirus and luciferase reporter system: 1
    • adapter molecule and luciferase activity: 1