Selected article for: "age year and cough fever"
Author: Mostaza, Jose M.; García-Iglesias, Francisca; González-Alegre, Teresa; Blanco, Francisco; Varas, Marta; Hernández-Blanco, Clara; Hontañón, Victor; Jaras-Hernández, María J.; Martínez-Prieto, Mónica; Menéndez-Saldaña, Araceli; Cachán, María L.; Estirado, Eva; Lahoz, Carlos
Title: Clinical course and prognostic factors of COVID-19 infection in an elderly hospitalized population
  • Cord-id: xb891utv
  • Document date: 2020_7_27
    • ID: xb891utv
    Snippet: INTRODUCTION: Older subjects have a higher risk of COVID-19 infection and a greater mortality. However, there is a lack of studies evaluating the characteristics of this infection at advanced age. PATIENTS AND METHODS: We studied 404 patients ≥ 75 years (mean age 85.2 ± 5.3 years, 55% males), with PCR-confirmed COVID-19 infection, attended in two hospitals in Madrid (Spain). Patients were followed-up until they were discharged from the hospital or until death. RESULTS: Symptoms started 2 to 7
    Document: INTRODUCTION: Older subjects have a higher risk of COVID-19 infection and a greater mortality. However, there is a lack of studies evaluating the characteristics of this infection at advanced age. PATIENTS AND METHODS: We studied 404 patients ≥ 75 years (mean age 85.2 ± 5.3 years, 55% males), with PCR-confirmed COVID-19 infection, attended in two hospitals in Madrid (Spain). Patients were followed-up until they were discharged from the hospital or until death. RESULTS: Symptoms started 2 to 7 days before admission, and consisted of fever (64%), cough (59%), and dyspnea (57%). A total of 145 patients (35.9%) died a median of 9 days after hospitalization. In logistic regression analysis, predictive factors of death were age (OR 1.086; 1.015-1.161 per year, p = 0.016), heart rate (1.040; 1.018-1.061 per beat, p < 0.0001), a decline in renal function during hospitalization (OR 7.270; 2.586-20.441, p < 0.0001) and worsening dyspnea during hospitalization (OR 73.616; 30.642-176.857, p < 0.0001). Factors predicting survival were a female sex (OR 0.271; 0.128-0.575, p = 0.001), previous treatment with RAAS inhibitors (OR 0.459; 0.222-0.949, p = 0.036), a higher oxygen saturation at admission (OR 0.901; 0.842-0.963 per percentage point increase, p = 0.002), and a greater platelet count (OR 0.995; 0.991-0.999 per 10(6)/L, p = 0.025). CONCLUSION: Elderly patients with COVID-19 infection have a similar clinical course to younger individuals. Previous treatment with RAAS inhibitors, and demographic, clinical and laboratory data influence prognosis.

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