Selected article for: "present study and study address"
Author: Cécilia Hognon; Tom Miclot; Cristina Garcia Iriepa; Antonio Francés-Monerris; Stephanie Grandemange; Alessio Terenzi; Marco Marazzi; Giampaolo Barone; Antonio Monari
Title: Role of RNA Guanine Quadruplexes in Favoring the Dimerization of SARS Unique Domain in Coronaviruses
  • Document date: 2020_4_10
    • ID: dnppshnv_11
    Snippet: The destabilization of the SUD/RNA complex, that could be achieved for instance by specific G4 ligands, or by competitors for the two G4 recognition spots evidenced in SUD, may constitute appealing potential therapeutic strategies. This is particularly true since these protein domains are shared by the family of SARS-type viruses and thus represent a molecular target that could stay operative in case of future mutations leading to new viral strai.....
    Document: The destabilization of the SUD/RNA complex, that could be achieved for instance by specific G4 ligands, or by competitors for the two G4 recognition spots evidenced in SUD, may constitute appealing potential therapeutic strategies. This is particularly true since these protein domains are shared by the family of SARS-type viruses and thus represent a molecular target that could stay operative in case of future mutations leading to new viral strains. As a continuation of the present work, we plan to address the study of the interaction between specific ligands and RNA G4 oligomers, also taking into account the perturbation induced on the recognition by SUD.

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