Author: Krishan Mohan Kapoor; Aanandita Kapoor
Title: Role of Chloroquine and Hydroxychloroquine in the Treatment of COVID-19 Infection- A Systematic Literature Review Document date: 2020_3_30
ID: 0lk8eujq_29
Snippet: HCQ has been found to be more potent than CQ at inhibiting SARS-CoV-2 in vitro. HCQ Sulfate 400 mg twice daily for one day, followed by 200 mg twice daily for four more days, has been recommended for treating COVID-19 infection. 19 Based on CQ's antiviral mechanisms, its laboratory activity against COVID-19, as well as CQ's pharmacokinetics based on its use for malaria and autoimmune diseases, safe and potentially efficacious dose regimens have b.....
Document: HCQ has been found to be more potent than CQ at inhibiting SARS-CoV-2 in vitro. HCQ Sulfate 400 mg twice daily for one day, followed by 200 mg twice daily for four more days, has been recommended for treating COVID-19 infection. 19 Based on CQ's antiviral mechanisms, its laboratory activity against COVID-19, as well as CQ's pharmacokinetics based on its use for malaria and autoimmune diseases, safe and potentially efficacious dose regimens have been recommended for protection against COVID-19. This protocol has pre-exposure prophylaxis of 250-500mg CQ daily and post-exposure prophylaxis at 8mg/kg/day CQ for three days. 24 All rights reserved. No reuse allowed without permission.
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