Author: Jiao Zhao; Yan Yang; Han-Ping Huang; Dong Li; Dong-Feng Gu; Xiang-Feng Lu; Zheng Zhang; Lei Liu; Ting Liu; Yu-Kun Liu; Yun-Jiao He; Bin Sun; Mei-Lan Wei; Guang-Yu Yang; Xinghuan Wang; Li Zhang; Xiao-Yang Zhou; Ming-Zhao Xing; Peng George Wang
Title: Relationship between the ABO Blood Group and the COVID-19 Susceptibility Document date: 2020_3_16
ID: 5sfojk7y_24
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.11.20031096 doi: medRxiv preprint O hospital staff had a lower chance of getting infected. Patrice et al. found that anti-A antibodies specifically inhibited the adhesion of SARS-CoV S protein-expressing cells to ACE2-expressing cell lines 7 . Given the nucleic acid sequence similarity 8 and receptor angiotensin-converting enzyme 2 (ACE2).....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.11.20031096 doi: medRxiv preprint O hospital staff had a lower chance of getting infected. Patrice et al. found that anti-A antibodies specifically inhibited the adhesion of SARS-CoV S protein-expressing cells to ACE2-expressing cell lines 7 . Given the nucleic acid sequence similarity 8 and receptor angiotensin-converting enzyme 2 (ACE2) binding similarity between SARS-CoV and SARS-CoV-2 9-11 , the lower susceptibility of blood group O and higher susceptibility of blood group A for COVID-19 could be linked to the presence of natural anti-blood group antibodies, particularly anti-A antibody, in the blood. This speculation will need direct studies to prove. There may also be other mechanisms underlying the ABO blood group-differentiated susceptibility for COVID-19 that require further studies to elucidate.
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