Author: Barata Kasal, Daniel Arthur; De Lorenzo, Andrea; Tibiriçá, Eduardo
Title: COVID-19 and Microvascular Disease: Pathophysiology of SARS-Cov-2 Infection With Focus on the Renin-Angiotensin System Cord-id: x256nbnc Document date: 2020_9_2
ID: x256nbnc
Snippet: The recently described severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions of people, with thousands of fatalities. It has prompted global efforts in research, with focus on the pathophysiology of coronavirus disease-19 (COVID-19), and a rapid surge of publications. COVID-19 has been associated with a myriad of clinical manifestations, including the lungs, heart, kidneys, central nervous system, gastrointestinal system, skin, and blood coagulation abnormalities. Th
Document: The recently described severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions of people, with thousands of fatalities. It has prompted global efforts in research, with focus on the pathophysiology of coronavirus disease-19 (COVID-19), and a rapid surge of publications. COVID-19 has been associated with a myriad of clinical manifestations, including the lungs, heart, kidneys, central nervous system, gastrointestinal system, skin, and blood coagulation abnormalities. The endothelium plays a key role in organ dysfunction associated with severe infection, and current data suggest that it is also involved in SARS-CoV-2-induced sepsis. This critical review aimed to address a possible unifying mechanism underlying the diverse complications of COVID-19: microvascular dysfunction, with emphasis on the renin-angiotensin system. In addition, research perspectives are suggested in order to expand understanding of the pathophysiology of the infection.
Search related documents:
Co phrase search for related documents- ace activation and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7
- ace inhibitor administration and acute respiratory syndrome: 1
- ace inhibitor and acute lung injury: 1, 2, 3, 4
- ace inhibitor and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- ace polymorphism and acute lung injury: 1, 2, 3, 4
- ace polymorphism and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- ace produce and acute respiratory syndrome: 1, 2, 3, 4
- acute lung injury and adaptive immune response: 1, 2, 3, 4, 5
- acute lung injury and adaptive immune response innate: 1, 2, 3, 4, 5
- acute lung injury and adhesion molecule: 1, 2, 3, 4, 5, 6, 7, 8
- acute respiratory syndrome and adaptive immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute respiratory syndrome and adaptive immune response innate: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute respiratory syndrome and adaptive process: 1, 2, 3, 4
- acute respiratory syndrome and adhesion molecule: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute respiratory syndrome and local increase: 1, 2, 3, 4, 5
- acute viral infection and adaptive immune response: 1, 2, 3, 4
- acute viral infection and adaptive process: 1
- adaptive immune response and adhesion molecule: 1, 2, 3
- adaptive immune response innate and adhesion molecule: 1
Co phrase search for related documents, hyperlinks ordered by date