Author: Aleksandra Milewska; Anna Kula-Pacurar; Jakub Wadas; Agnieszka Suder; Artur Szczepanski; Agnieszka Dabrowska; Katarzyna Owczarek; Marek Ochman; Tomasz Stacel; Zenon Rajfur; Pawel Piotr Labaj; Wojciech Branicki; Krzysztof Pyrc
Title: Replication of SARS-CoV-2 in human respiratory epithelium Document date: 2020_3_21
ID: 1cc9ig04_3
Snippet: At present, the studies on the virus are carried out using a surrogate system based on the 55 immortalized simian Vero E6 cell line 11 . While this model is convenient for diagnostics and 56 testing of some antiviral drugs, it has serious limitations and does not allow for the 57 understanding of virus biology and evolution. To make an example, the entry route of human 58 coronaviruses varies between the cell lines and differentiated tissue, not .....
Document: At present, the studies on the virus are carried out using a surrogate system based on the 55 immortalized simian Vero E6 cell line 11 . While this model is convenient for diagnostics and 56 testing of some antiviral drugs, it has serious limitations and does not allow for the 57 understanding of virus biology and evolution. To make an example, the entry route of human 58 coronaviruses varies between the cell lines and differentiated tissue, not mentioning the immune 59 responses or virus-host interactions 12, 13, 14 .
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