Author: Oladipo, Elijah Kolawole; Ajayi, Ayodeji Folorunsho; Onile, Olugbenga Samson; Ariyo, Olumuyiwa Elijah; Jimah, Esther Moradeyo; Ezediuno, Louis Odinakaose; Adebayo, Oluwadunsin Iyanuoluwa; Adebayo, Emmanuel Tayo; Odeyemi, Aduragbemi Noah; Oyeleke, Marvellous Oluwaseun; Oyewole, Moyosoluwa Precious; Oguntomi, Ayomide Samuel; Akindiya, Olawumi Elizabeth; Aremu, Victoria Oyetayo; Aboderin, Dorcas Olubunmi; Oloke, Julius Kola
Title: Designing a conserved peptide-based subunit vaccine against SARS-CoV-2 using immunoinformatics approach Cord-id: p2ndh2z7 Document date: 2021_1_6
ID: p2ndh2z7
Snippet: The widespread of coronavirus (COVID-19) is a new global health crisis that poses a threat to the world. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated in bats and was discovered first in Wuhan, Hubei province, China in December 2019. Immunoinformatics and bioinformatics tools were employed for the construction of a multi-epitope subunit vaccine to prevent the diseases. The antigenicity, toxicity and allergenicity of all epitopes used in the construction of the vacci
Document: The widespread of coronavirus (COVID-19) is a new global health crisis that poses a threat to the world. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated in bats and was discovered first in Wuhan, Hubei province, China in December 2019. Immunoinformatics and bioinformatics tools were employed for the construction of a multi-epitope subunit vaccine to prevent the diseases. The antigenicity, toxicity and allergenicity of all epitopes used in the construction of the vaccine were predicted and then conjugated with adjuvants and linkers. Vaccine Toll-Like Receptors (2, 3, 4, 8 and 9) complex was also evaluated. The vaccine construct was antigenic, non-toxic and non-allergic, which indicates the vaccines ability to induce antibodies in the host, making it an effective vaccine candidate. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40203-020-00062-x.
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