Author: Yafei Wang; Randy Heiland; Morgan Craig; Courtney L. Davis; Ashlee N Ford Versypt; Adrianne Jenner; Jonathan Ozik; Nicholson Collier; Chase Cockrell; Andrew Becker; Gary An; James A. Glazier; Aarthi Narayanan; Amber M Smith; Paul Macklin
Title: Rapid community-driven development of a SARS-CoV-2 tissue simulator Document date: 2020_4_5
ID: lq4tcyh4_155
Snippet: We next tested the effect of releasing all assembled viral particles at the time of cell death by setting frelease = 1. For this set of model parameters, the release of assembled virions had a negligent impact of the overall spread of infection: Compare the final frame of row B (no release: frelease = 0) to row C (compete release: frelease = 1) in Figure 3 . This is because cells release far more virions during their infected lifetimes, so the ef.....
Document: We next tested the effect of releasing all assembled viral particles at the time of cell death by setting frelease = 1. For this set of model parameters, the release of assembled virions had a negligent impact of the overall spread of infection: Compare the final frame of row B (no release: frelease = 0) to row C (compete release: frelease = 1) in Figure 3 . This is because cells release far more virions during their infected lifetimes, so the effect is dominant over the one-time release of virions at cell death. We expect this behavior would change if the cells exocytosed virions more slowly.
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