Author: Martin Bartas; Václav Brázda; Natália Bohálová; Alessio Cantara; Adriana Volná; Tereza Stachurová; Katerina Malachová; Eva B. Jagelská; Otília Porubiaková; Jirí Cerven; Petr Pecinka
Title: In-depth Bioinformatic Analyses of Human SARS-CoV-2, SARS-CoV, MERS-CoV, and Other Nidovirales Suggest Important Roles of Noncanonical Nucleic Acid Structures in Their Lifecycles Document date: 2020_4_11
ID: d3q0xel1_42
Snippet: Nevertheless, Nsp3's role is still largely unknown. It is believed that the protein plays various roles in coronavirus infection. Nsp3 interacts with other viral Nsps as well as RNA to form the replication/transcription complex. It also acts on posttranslational modifications of host proteins to antagonize the host innate immune response. On the other hand, Nsp3 is itself modified in host cells by N-glycosylation and can interact with host protei.....
Document: Nevertheless, Nsp3's role is still largely unknown. It is believed that the protein plays various roles in coronavirus infection. Nsp3 interacts with other viral Nsps as well as RNA to form the replication/transcription complex. It also acts on posttranslational modifications of host proteins to antagonize the host innate immune response. On the other hand, Nsp3 is itself modified in host cells by N-glycosylation and can interact with host proteins to support virus survival (Lei et al., 2018) . Both SARS-CoVs (2003 and have the PQSs in their genomes and have a retained M region of the SUD domain in protein Nsp3 that is reported to be critical for interacting with G-quadruplexes (Kusov et al., 2015) . MERS has no PQS in its RNA sequence and, strikingly, it has a deletion in this region of the SUD domain suggesting parallel evolution simplifications.
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