Author: Martin Bartas; Václav Brázda; Natália Bohálová; Alessio Cantara; Adriana Volná; Tereza Stachurová; Katerina Malachová; Eva B. Jagelská; Otília Porubiaková; Jirí Cerven; Petr Pecinka
Title: In-depth Bioinformatic Analyses of Human SARS-CoV-2, SARS-CoV, MERS-CoV, and Other Nidovirales Suggest Important Roles of Noncanonical Nucleic Acid Structures in Their Lifecycles Document date: 2020_4_11
ID: d3q0xel1_57
Snippet: Because all the aforementioned cases concern RNA viruses, the viral G-quadruplexes are localized in the cytoplasm of the host cell. One of the main conclusions to be drawn from this study is that sequences able to form G-quadruplex structures in the Nidovirales (infecting human) family are very rare, and this suggests intentional suppression during evolution to simplify viral RNA replication......
Document: Because all the aforementioned cases concern RNA viruses, the viral G-quadruplexes are localized in the cytoplasm of the host cell. One of the main conclusions to be drawn from this study is that sequences able to form G-quadruplex structures in the Nidovirales (infecting human) family are very rare, and this suggests intentional suppression during evolution to simplify viral RNA replication.
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