Selected article for: "cell virus and membrane fusion"
Author: Umar Faruq Chowdhury; Mohammad Umer Sharif Shohan; Kazi Injamamul Hoque; Mirza Ashikul Beg; Mohammad Ali Moni; Mohammad Kawsar Sharif Siam
Title: A Computational Approach to Design Potential siRNA Molecules as a Prospective Tool for Silencing Nucleocapsid Phosphoprotein and Surface Glycoprotein Gene of SARS-CoV-2
  • Document date: 2020_4_12
    • ID: exoc6xvt_7
    Snippet: mediates virus entry to cell [22] . S contains two functional subunits: S1 & S2 subunits. The S1 69 subunit includes the receptor-binding domain(s) and contributes to stabilization of the membrane-70 anchored S2 subunit that contains the fusion machinery [23] . As the coronavirus S glycoprotein is 71 surface-exposed and mediates entry into host cells and N nucleocapsid protein are essential for 72 genome replication, these could be the main targe.....
    Document: mediates virus entry to cell [22] . S contains two functional subunits: S1 & S2 subunits. The S1 69 subunit includes the receptor-binding domain(s) and contributes to stabilization of the membrane-70 anchored S2 subunit that contains the fusion machinery [23] . As the coronavirus S glycoprotein is 71 surface-exposed and mediates entry into host cells and N nucleocapsid protein are essential for 72 genome replication, these could be the main targets for designing therapeutics [24] . 73 74 Table 1 Rules/Algorithm to construct siRNAs.

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