Selected article for: "enrichment analysis and MOA action"
Author: Jing Xing; Rama Shankar; Aleksandra Drelich; Shreya Paithankar; Eugene Chekalin; Thomas Dexheimer; Surender Rajasekaran; Chien-Te Kent Tseng; Bin Chen
Title: Reversal of Infected Host Gene Expression Identifies Repurposed Drug Candidates for COVID-19
  • Document date: 2020_4_9
    • ID: dl6rbqxp_11
    Snippet: Mechanism of action (MoA) enrichment analysis of the final ranked drug list revealed a few significant drug classes including CDK inhibitors, mTOR inhibitors and NF-κB pathway inhibitors ( Figure 2B ). Lately, Jeon et al. 21 tested the antiviral efficacy of 35 FDA-approved drugs against SARS-CoV-2, among which 14 positive drugs overlapped with our screening library. These drugs were also significantly enriched at the top of our prediction ( Figu.....
    Document: Mechanism of action (MoA) enrichment analysis of the final ranked drug list revealed a few significant drug classes including CDK inhibitors, mTOR inhibitors and NF-κB pathway inhibitors ( Figure 2B ). Lately, Jeon et al. 21 tested the antiviral efficacy of 35 FDA-approved drugs against SARS-CoV-2, among which 14 positive drugs overlapped with our screening library. These drugs were also significantly enriched at the top of our prediction ( Figure 2C , p = 1.39E-4), further validating our predictions. Interestingly, three antiparasite drugs pyrvinium, ivermectin, niclosamide were ranked among the top 30. Both ivermectin, and niclosamide could inhibit the replication of SARS-CoV-2 in vitro 21, 22 and pyrvinium and niclosamide were effective in MERS and SARS 23, 24 .

    Search related documents:
    Co phrase search for related documents
    • action mechanism and drug class: 1, 2, 3, 4, 5, 6
    • action mechanism and drug list: 1
    • action mechanism and MoA action mechanism: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • action mechanism and mTOR inhibitor: 1, 2
    • action mechanism and pathway inhibitor: 1, 2
    • action mechanism and positive drug: 1
    • antiviral efficacy and drug class: 1
    • antiviral efficacy and mTOR inhibitor: 1
    • antiviral efficacy and positive drug: 1
    • CDK inhibitor and positive drug: 1
    • drug class and mTOR inhibitor: 1
    • drug class and pathway inhibitor: 1
    • drug list and positive drug: 1
    • mTOR inhibitor and pathway inhibitor: 1, 2, 3
    • NF κB pathway inhibitor and pathway inhibitor: 1, 2, 3