Oral lesions associated with COVID-19: A systematic review.

Uzêda-E-Silva, Virgínia Dias; de Sá, Isabella Brandão; Martins, Jakeline; Pedreira, Novaes; Vieira, Victória Pamponet Souza; Silva, Bárbara Helem de Moraes

BACKGROUND Oral lesions has been reported in coronavirus disease 2019 (COVID-19). However, there are gaps about the occurrence. The aim of this study was to describe the clinical characteristics of oral lesions in patients with COVID-19. METHODS A systematic review was conducted in four electronic databases (PubMed, Lilacs, Cochrane and Google Scholar) with the search terms: "coronavírus", "COVID-19", "SARS-CoV-2", "novel coronavírus", "2019nCoV", "oral manifestation", "mucosal lesions", "oral lesions", "mucosa viral lesions" and "oral conditions". Articles were limited to those published between january and july 2020, and in English. RESULTS Initially, 182 articles were found, after reading the titles and abstracts a total of 24 records were included for full-text reading. Finally, 22 articles were included for data extraction and assessement. We identified and subsequently discussed clinical characteristics and differential diagnosis. CONCLUSIONS The etiology of many oral mucosal lesions is intimately related to infectious, immunological, and psychosocial factors. Therefore, amid the SARS-CoV-2 pandemic in which many doubts about the disease still remain, caution is needed when evaluating patients and establishing correlations with other diseases that could be associated.