Selected article for: "cov protein and different sequence"
Author: Chunyun Sun; Long Chen; Ji Yang; Chunxia Luo; Yanjing Zhang; Jing Li; Jiahui Yang; Jie Zhang; Liangzhi Xie
Title: SARS-CoV-2 and SARS-CoV Spike-RBD Structure and Receptor Binding Comparison and Potential Implications on Neutralizing Antibody and Vaccine Development
  • Document date: 2020_2_20
    • ID: nhq0oq8y_20
    Snippet: Coronavirus' mutation and emergence of escape mutants to neutralizing monoclonal antibodies and vaccines are a major concern. SARS-CoV-2 and SARS-CoV are two different coronaviruses with modest level of sequence homology in their spike proteins. Understanding whether antibodies raised from SARS-CoV spike protein immunization have cross-reactivity to the new SARS-CoV-2 will offer important insights and guidance to therapeutic antibody and prophyla.....
    Document: Coronavirus' mutation and emergence of escape mutants to neutralizing monoclonal antibodies and vaccines are a major concern. SARS-CoV-2 and SARS-CoV are two different coronaviruses with modest level of sequence homology in their spike proteins. Understanding whether antibodies raised from SARS-CoV spike protein immunization have cross-reactivity to the new SARS-CoV-2 will offer important insights and guidance to therapeutic antibody and prophylactic vaccine development.

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