Author: Kerget, Ferhan; Kerget, Buğra; İba Yılmaz, Sibel; Kızıltunç, Ahmet
Title: Evaluation of the relationship between TREMâ€1/TREMâ€2 ratio and clinical course in COVIDâ€19 pneumonia Cord-id: y5rt0807 Document date: 2021_8_8
ID: y5rt0807
Snippet: OBJECTIVE: The inflammatory/antiâ€inflammatory balance has an important role in the clinical course of SARSâ€CoVâ€2 infection (COVIDâ€19), which has affected over 100 million people since it first appeared in China in December 2019. The aim of this study was to investigate the relationship between triggering receptor expressed on myeloid cells (TREM)â€1/TREMâ€2 ratio and COVIDâ€19 severity. METHODS: A total of 171 individuals were included in the study: 121 patients who were admitted to t
Document: OBJECTIVE: The inflammatory/antiâ€inflammatory balance has an important role in the clinical course of SARSâ€CoVâ€2 infection (COVIDâ€19), which has affected over 100 million people since it first appeared in China in December 2019. The aim of this study was to investigate the relationship between triggering receptor expressed on myeloid cells (TREM)â€1/TREMâ€2 ratio and COVIDâ€19 severity. METHODS: A total of 171 individuals were included in the study: 121 patients who were admitted to the chest diseases department and intensive care unit of our hospital and diagnosed with COVIDâ€19 by realâ€time PCR of nasopharyngeal swab samples from December 2020 to March 2021 and a control group consisting of 50 asymptomatic health workers in our hospital who had negative realâ€time PCR results during routine COVIDâ€19 screening. RESULTS: TREMâ€1 level was significantly higher in patients with severe disease compared with the moderate and control groups (P = .003, P = .001). TREMâ€2 levels did not differ significantly in moderate and severe patients (P = .36) but were significantly higher in both patient groups compared with the control group (P = .001 for both). TREMâ€1/TREMâ€2 ratio was significantly higher in the severe patient group than in the moderate and control groups (P = .001 for both). In receiver operating characteristic curve analysis of TREMâ€1/TREMâ€2 ratio in patients with moderate and severe COVIDâ€19, the area under the curve was 0.723. Using a cutâ€off value of 0.125 for TREMâ€1/TREMâ€2 ratio in the Youden index calculation, the sensitivity was 60% and specificity was 71%. CONCLUSION: Experience with the positive effects of medical treatments to restore inflammatory balance in the course of COVIDâ€19 is steadily increasing. TREMâ€1 and TREMâ€2 have an important role in inflammation and may serve as biomarkers and therapeutic targets in the early treatment and followâ€up of COVIDâ€19.
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