Selected article for: "CoV virion and host cell"
Author: Chunyun Sun; Long Chen; Ji Yang; Chunxia Luo; Yanjing Zhang; Jing Li; Jiahui Yang; Jie Zhang; Liangzhi Xie
Title: SARS-CoV-2 and SARS-CoV Spike-RBD Structure and Receptor Binding Comparison and Potential Implications on Neutralizing Antibody and Vaccine Development
  • Document date: 2020_2_20
    • ID: nhq0oq8y_37
    Snippet: Though it is difficult to assess the virus-host-cell interactions with real virion, we studied the new SARS-CoV-2 in head-to-head comparisons with SARS-CoV using multiple methods. Measurements of recombinant SARS-CoV-2 and SARS-CoV spike proteins to recombinant ACE2 protein and ACE2 expressing 293T cells confirmed the two coronaviruses' similar binding affinities to human ACE2 (Figure 2A&B) , which provided direct molecular based evidences to sup.....
    Document: Though it is difficult to assess the virus-host-cell interactions with real virion, we studied the new SARS-CoV-2 in head-to-head comparisons with SARS-CoV using multiple methods. Measurements of recombinant SARS-CoV-2 and SARS-CoV spike proteins to recombinant ACE2 protein and ACE2 expressing 293T cells confirmed the two coronaviruses' similar binding affinities to human ACE2 (Figure 2A&B) , which provided direct molecular based evidences to support and possibly explain the observation that the new SARS-CoV-2 coronavirus has similar transmissibility to SARS-CoV virus.

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