Author: Li, Jingyi; Mo, Chunfen; Guo, Yifan; Zhang, Bowen; Feng, Xiao; Si, Qiuyue; Wu, Xiaobo; Zhao, Zhe; Gong, Lixin; He, Dan; Shao, Jichun
Title: Roles of peptidyl-prolyl isomerase Pin1 in disease pathogenesis Cord-id: xm02ydmm Document date: 2021_1_19
ID: xm02ydmm
Snippet: Pin1 belongs to the peptidyl-prolyl cis-trans isomerases (PPIases) superfamily and catalyzes the cis-trans conversion of proline in target substrates to modulate diverse cellular functions including cell cycle progression, cell motility, and apoptosis. Dysregulation of Pin1 has wide-ranging influences on the fate of cells; therefore, it is closely related to the occurrence and development of various diseases. This review summarizes the current knowledge of Pin1 in disease pathogenesis.
Document: Pin1 belongs to the peptidyl-prolyl cis-trans isomerases (PPIases) superfamily and catalyzes the cis-trans conversion of proline in target substrates to modulate diverse cellular functions including cell cycle progression, cell motility, and apoptosis. Dysregulation of Pin1 has wide-ranging influences on the fate of cells; therefore, it is closely related to the occurrence and development of various diseases. This review summarizes the current knowledge of Pin1 in disease pathogenesis.
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