Selected article for: "human population and rapid spread"
Author: Jessica E. Manning; Jennifer A. Bohl; Sreyngim Lay; Sophana Chea; Ly Sovann; Yi Sengdoeurn; Seng Heng; Chan Vuthy; Katrina Kalantar; Vida Ahyong; Michelle Tan; Jonathan Sheu; Cristina M. Tato; Joseph L. DeRisi; Laurence Baril; Veasna Duong; Philippe Dussart; Erik A. Karlsson
Title: Rapid metagenomic characterization of a case of imported COVID-19 in Cambodia
  • Document date: 2020_3_5
    • ID: fu3cl7lq_1
    Snippet: The ongoing outbreak of a novel coronavirus in China is now evident in 37 other countries as others employ vigilant screening procedures. 1 As of 24 Feb 2020, 119 SARS-CoV-2 genome sequences from 15 countries are publicly available from over 79,331 confirmed cases. 1,2 These viral genomes differ by only 0 to 5 mutations, likely representing a single introduction in the human population from an unknown reservoir or intermediate host, potentially b.....
    Document: The ongoing outbreak of a novel coronavirus in China is now evident in 37 other countries as others employ vigilant screening procedures. 1 As of 24 Feb 2020, 119 SARS-CoV-2 genome sequences from 15 countries are publicly available from over 79,331 confirmed cases. 1,2 These viral genomes differ by only 0 to 5 mutations, likely representing a single introduction in the human population from an unknown reservoir or intermediate host, potentially bats. 3 Subsequently, the virus rapidly spread since December 2019. Currently, incubation period and transmissibility are questions of global concern, but difficult to answer given nonspecific and mild symptoms that could represent a variety of respiratory viruses. 4, 5 Genetic characterization of the virus from geographically diverse patient samples is key to infer the rate of spread. Additionally, rapid and complete results from cases worldwide are important for sequence-dependent countermeasures and accurate diagnostics. However, as the virus reaches resource-limited settings in proximity to the outbreak's epicenter, such as Cambodia, Laos, and Myanmar, there are often logistical challenges in surveillance, contact tracing, sample collection, and biospecimen transport. Information delay is also compounded by a dearth of sequencing and/or bioinformatics expertise in-country, further postponing analysis and dissemination of pathogen genomic information.

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