Selected article for: "amino acid sequence and Homology modeling"
Author: Chunyun Sun; Long Chen; Ji Yang; Chunxia Luo; Yanjing Zhang; Jing Li; Jiahui Yang; Jie Zhang; Liangzhi Xie
Title: SARS-CoV-2 and SARS-CoV Spike-RBD Structure and Receptor Binding Comparison and Potential Implications on Neutralizing Antibody and Vaccine Development
  • Document date: 2020_2_20
    • ID: nhq0oq8y_8
    Snippet: The structure model for SARS-CoVRBD-ACE2 complex was optimized based on the complex's crystal structure (PDB ID: 2AJF) (http://www.rcsb.org/). The structure model for SARS-CoV-2 RBD-ACE2 complex was constructed by homology modeling using the optimized SARS-CoV RBD-ACE2 complex crystal structure as a template, based on a 73.7% amino acid sequence homology between the two viruses. Root-mean-square deviation (RMSD) of Cα atoms between the two compl.....
    Document: The structure model for SARS-CoVRBD-ACE2 complex was optimized based on the complex's crystal structure (PDB ID: 2AJF) (http://www.rcsb.org/). The structure model for SARS-CoV-2 RBD-ACE2 complex was constructed by homology modeling using the optimized SARS-CoV RBD-ACE2 complex crystal structure as a template, based on a 73.7% amino acid sequence homology between the two viruses. Root-mean-square deviation (RMSD) of Cα atoms between the two complex structures is 0.703 Å, indicating an almost identical structural conformation (Figure1B). There are subtle differences in the RBD-ACE2 interfaces between SARS-CoV-2 and SARS-CoV at the loop 469-470 (numbered according to SARS-CoV RBD), arising from a one-residue insertion after residue 469 ( Figure 1A) .

    Search related documents:
    Co phrase search for related documents
    • amino acid and complex structure: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • amino acid and crystal structure: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • amino acid and homology modeling: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • amino acid and residue insertion: 1, 2, 3, 4
    • amino acid and RMSD root mean square deviation: 1, 2, 3, 4, 5, 6
    • amino acid and root mean square deviation: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • amino acid and sequence homology: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • amino acid and structural conformation: 1, 2, 3, 4, 5
    • amino acid and structure model: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • amino acid virus sequence homology and sequence homology: 1
    • Cα RMSD root mean square deviation and RMSD root mean square deviation: 1, 2
    • Cα RMSD root mean square deviation and root mean square deviation: 1, 2
    • complex crystal structure and crystal structure: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • complex crystal structure and homology modeling: 1
    • complex crystal structure and residue insertion: 1
    • complex crystal structure and RMSD root mean square deviation: 1
    • complex crystal structure and root mean square deviation: 1
    • complex crystal structure and structure model: 1, 2, 3, 4, 5, 6, 7, 8
    • complex structure and root mean square deviation: 1