Author: Mankelow, Tosti J.; Singleton, Belinda K.; Moura, Pedro L.; Stevensâ€Hernandez, Christian J.; Cogan, Nicola M.; Gyorffy, Gyongyver; Kupzig, Sabine; Nichols, Luned; Asby, Claire; Pooley, Jennifer; Ruffino, Gabriella; Hosseini, Faroakh; Moghaddas, Fiona; Attwood, Marie; Noel, Alan; Cooper, Alex; Arnold, David T.; Hamilton, Fergus; Hyams, Catherine; Finn, Adam; Toye, Ashley M.; Anstee, David J.
Title: Blood group type A secretors are associated with a higher risk of COVIDâ€19 cardiovascular disease complications Cord-id: tgndqsa0 Document date: 2021_4_2
ID: tgndqsa0
Snippet: The SARSâ€CoVâ€2 virus causes COVIDâ€19, an infection capable of causing severe disease and death but which can also be asymptomatic or oligosymptomatic. We investigated whether ABO blood group or secretor status was associated with COVIDâ€19 severity. We investigated secretor status because expression of ABO glycans on secreted proteins and nonâ€erythroid cells are controlled by a fucosyltransferase (FUT2), and inactivating FUT2 mutations result in a nonâ€secretor phenotype which protects
Document: The SARSâ€CoVâ€2 virus causes COVIDâ€19, an infection capable of causing severe disease and death but which can also be asymptomatic or oligosymptomatic. We investigated whether ABO blood group or secretor status was associated with COVIDâ€19 severity. We investigated secretor status because expression of ABO glycans on secreted proteins and nonâ€erythroid cells are controlled by a fucosyltransferase (FUT2), and inactivating FUT2 mutations result in a nonâ€secretor phenotype which protects against some viral infections. Data combined from healthcare records and our own laboratory tests (n = 275) of hospitalized SARSâ€CoVâ€2 polymerase chain reaction positive patients confirmed higher than expected numbers of blood group A individuals compared to O (RR = 1.24, CI 95% [1.05, 1.47], p = 0.0111). There was also a significant association between group A and COVIDâ€19â€related cardiovascular complications (RR = 2.56, CI 95% [1.43, 4.55], p = 0.0011) which is independent of gender. Molecular analysis revealed that group A nonâ€secretors are significantly less likely to be hospitalized than secretors. Testing of convalescent plasma donors, among whom the majority displayed COVIDâ€19 symptoms and only a small minority required hospitalization, group A nonâ€secretors were slightly overâ€represented. Our findings showed that group A nonâ€secretors are not resistant to infection by SARSâ€CoVâ€2, but are more likely to experience a less severe form of associated disease.
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