Author: To, KF; Tong, Joanna HM; Chan, Paul KS; Au, Florence WL; Chim, Stephen SC; Allen Chan, KC; Cheung, Jo LK; Liu, Esther YM; Tse, Gary MK; Lo, Anthony WI; Dennis Lo, YM; Ng, HK
Title: Tissue and cellular tropism of the coronavirus associated with severe acute respiratory syndrome: an inâ€situ hybridization study of fatal cases Cord-id: poqzfw1w Document date: 2004_1_19
ID: poqzfw1w
Snippet: Severe acute respiratory syndrome (SARS) is a new human infectious disease with significant morbidity and mortality. The disease has been shown to be associated with a new coronavirus (SARSâ€CoV). The clinical and epidemiological aspects of SARS have been described. Moreover, the viral genome of SARSâ€CoV has been fully sequenced. However, much of the biological behaviour of the virus is not known and data on the tissue and cellular tropism of SARSâ€CoV are limited. In this study, six fatal c
Document: Severe acute respiratory syndrome (SARS) is a new human infectious disease with significant morbidity and mortality. The disease has been shown to be associated with a new coronavirus (SARSâ€CoV). The clinical and epidemiological aspects of SARS have been described. Moreover, the viral genome of SARSâ€CoV has been fully sequenced. However, much of the biological behaviour of the virus is not known and data on the tissue and cellular tropism of SARSâ€CoV are limited. In this study, six fatal cases of SARS were investigated for the tissue and cellular tropism of SARSâ€CoV using an inâ€situ hybridization (ISH) technique. Among all the tissues studied, positive signals were seen in pneumocytes in the lungs and surface enterocytes in the small bowel. Infected pneumocytes were further confirmed by immunofluorescence–fluorescence inâ€situ hybridization (FISH) analysis. These results provide important information concerning the tissue tropism of SARSâ€CoV, which is distinct from previously identified human coronaviruses, and suggest the possible involvement of novel receptors in this infection. Whereas the lung pathology was dominated by diffuse alveolar damage, the gut was relatively intact. These findings indicated that tissue responses to SARSâ€CoV infection are distinct in different organs. Copyright © 2004 John Wiley & Sons, Ltd.
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