Selected article for: "genetic variation and genome sequencing"
Author: William T Gibson; Daniel M Evans; Jianghong An; Steven JM Jones
Title: ACE 2 Coding Variants: A Potential X-linked Risk Factor for COVID-19 Disease
  • Document date: 2020_4_14
    • ID: 05w8tv8x_3
    Snippet: Though we are aware that full genome-wide and exome-wide sequencing studies may 44 ultimately be required to assess human genetic susceptibility to SARS-CoV-2 fully, we argue on the 45 basis of strong prior probabilities that genotyping of this class of alleles is justified in cases of atypical 46 SARS-CoV-2 diseases, such as asymptomatic super-spreaders (if any are identified), and in 47 human host genetic variation has long been recognized as m.....
    Document: Though we are aware that full genome-wide and exome-wide sequencing studies may 44 ultimately be required to assess human genetic susceptibility to SARS-CoV-2 fully, we argue on the 45 basis of strong prior probabilities that genotyping of this class of alleles is justified in cases of atypical 46 SARS-CoV-2 diseases, such as asymptomatic super-spreaders (if any are identified), and in 47 human host genetic variation has long been recognized as mitigating the outcome of infestation by 70 malarial parasites (reviewed by Kariuki and Williams 15 ) . 71

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