Selected article for: "generation sequencing and NGS generation sequencing"
Author: Timokratis Karamitros; Gethsimani Papadopoulou; Maria Bousali; Anastasios Mexias; Sotiris Tsiodras; Andreas Mentis
Title: SARS-CoV-2 exhibits intra-host genomic plasticity and low-frequency polymorphic quasispecies
  • Document date: 2020_3_28
    • ID: jxm69ndw_4
    Snippet: Here, we explore intra-host genomic variants and low-frequency polymorphic quasispecies in Next Generation Sequencing (NGS) data derived from patients infected by SARS-CoV-2. Our analyses provide insights into the intra-patient pool of viral genomes, identify the frequency levels of rare variants and highlight variable genomic regions and a potential recombination hot-spot within S gene. Intra-host genomic variability is critical for the developm.....
    Document: Here, we explore intra-host genomic variants and low-frequency polymorphic quasispecies in Next Generation Sequencing (NGS) data derived from patients infected by SARS-CoV-2. Our analyses provide insights into the intra-patient pool of viral genomes, identify the frequency levels of rare variants and highlight variable genomic regions and a potential recombination hot-spot within S gene. Intra-host genomic variability is critical for the development of novel drugs and vaccines, which are of urgent necessity, towards the containment of this newly emerging epidemic. author/funder. All rights reserved. No reuse allowed without permission.

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