Author: Ryu, Jae Kyu; Sozmen, Elif G.; Dixit, Karuna; Montano, Mauricio; Matsui, Yusuke; Liu, Yixin; Helmy, Ekram; Deerinck, Thomas J.; Yan, Zhaoqi; Schuck, Renaud; Acevedo, Rosa Meza; Spencer, Collin M.; Thomas, Reuben; Pico, Alexander R.; Zamvil, Scott S.; Lynch, Kara L.; Ellisman, Mark H.; Greene, Warner C.; Akassoglou, Katerina
Title: SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy Cord-id: urk8aa5b Document date: 2021_10_13
ID: urk8aa5b
Snippet: Blood clots are a central feature of coronavirus disease-2019 (COVID-19) and can culminate in pulmonary embolism, stroke, and sudden death. However, it is not known how abnormal blood clots form in COVID-19 or why they occur even in asymptomatic and convalescent patients. Here we report that the Spike protein from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the blood coagulation factor fibrinogen and induces structurally abnormal blood clots with heightened proinflammat
Document: Blood clots are a central feature of coronavirus disease-2019 (COVID-19) and can culminate in pulmonary embolism, stroke, and sudden death. However, it is not known how abnormal blood clots form in COVID-19 or why they occur even in asymptomatic and convalescent patients. Here we report that the Spike protein from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the blood coagulation factor fibrinogen and induces structurally abnormal blood clots with heightened proinflammatory activity. SARS-CoV-2 Spike virions enhanced fibrin-mediated microglia activation and induced fibrinogen-dependent lung pathology. COVID-19 patients had fibrin autoantibodies that persisted long after acute infection. Monoclonal antibody 5B8, targeting the cryptic inflammatory fibrin epitope, inhibited thromboinflammation. Our results reveal a procoagulant role for the SARS-CoV-2 Spike and propose fibrin-targeting interventions as a treatment for thromboinflammation in COVID-19. One-Sentence Summary SARS-CoV-2 spike induces structurally abnormal blood clots and thromboinflammation neutralized by a fibrin-targeting antibody.
Search related documents:
Co phrase search for related documents- abnormal clotting and acute respiratory syndrome coronavirus: 1
- abnormal coagulation and acute infection: 1, 2, 3, 4
- abnormal coagulation and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22
- abnormal coagulation and acute respiratory syndrome coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- abnormal coagulation and acutely ill: 1
- acute infection and adenine dinucleotide phosphate: 1, 2, 3
- acute infection and adequate anticoagulation: 1, 2
- acute respiratory syndrome and adenine dinucleotide phosphate: 1, 2, 3, 4, 5
- acute respiratory syndrome and adequate anticoagulation: 1, 2
- acute respiratory syndrome coronavirus and adenine dinucleotide phosphate: 1, 2, 3, 4
- acute respiratory syndrome coronavirus and adequate anticoagulation: 1, 2
Co phrase search for related documents, hyperlinks ordered by date