Saposhnikovia divaricata—An Ethnopharmacological, Phytochemical and Pharmacological Review

Yang, Min; Wang, Cong-cong; Wang, Wen-le; Xu, Jian-ping; Wang, Jie; Zhang, Chun-hong; Li, Min-hui

Saposhnikovia divaricata (Turcz.) Schischk., a perennial herb belonging to the family Umbelliferae, is widely distributed in Northeast Asia. Its dried root (Radix Saposhnikoviae) is used as a Chinese herbal medicine for the treatment of immune system, nervous system, and respiratory diseases. Phytochemical and pharmacological studies have shown that the main constituents of S. divaricata are chromones, coumarins, acid esters, and polyacetylenes, and these compounds exhibited significant anti-inflammatory, analgesic, antioxidant, antiproliferative, antitumor, and immunoregulatory activities. The purpose of this review is to provide comprehensive information on the botanical characterization and distribution, traditional use and ethnopharmacology, phytochemistry, and pharmacology of S. divaricata for further study concerning its mechanism of action and development of better therapeutic agents and health products from S. divaricata. ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material (Appendixes 1–10) is available in the online version of this article at 10.1007/s11655-020-3091-x.