Author: Evseenko, Vasily A.; Svyatchenko, Svetlana V.; Kolosova, Natalia P.; Kovrizhkina, Valentina L.; Marchenko, Vasiliy Y.; Durymanov, Aleksander G.; Goncharova, Natalia I.; Ryzhikov, Alexander B.
Title: Comparative thermostability analysis of zoonotic and human influenza virus A and B neuraminidase Cord-id: pqt86rs7 Document date: 2019_11_19
ID: pqt86rs7
Snippet: Neuraminidase (NA) thermostability of influenza A and B viruses isolated from birds, swine and humans was measured to evaluate its variability associated with host body temperature. The highest 50% inactivation temperature (IT(50)) was observed with H3N8 avian influenza virus (74 °C), and the lowest IT(50) was observed with the seasonal human H3N2 virus (45.5 °C). The IT(50) values of A(H1N1)pdm09 viruses 56.4-58.5 °C were statistically higher than that of the prepandemic strain A/Solomon Isl
Document: Neuraminidase (NA) thermostability of influenza A and B viruses isolated from birds, swine and humans was measured to evaluate its variability associated with host body temperature. The highest 50% inactivation temperature (IT(50)) was observed with H3N8 avian influenza virus (74 °C), and the lowest IT(50) was observed with the seasonal human H3N2 virus (45.5 °C). The IT(50) values of A(H1N1)pdm09 viruses 56.4-58.5 °C were statistically higher than that of the prepandemic strain A/Solomon Islands/03/06 (52.5 °C). An analysis of Ca(2+) binding sites revealed the correspondence of amino acid changes to NA thermostability. This study demonstrates that changes in NA thermostability correspond to differences in host body temperature.
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