The influence of pre-existing hypertension on coronavirus disease 2019 patients

Wei, Zhi-Yao; Qiao, Rui; Chen, Jian; Huang, Ji; Wu, Hui; Wang, Wen-Jun; Yu, Hua; Xu, Jing; Wang, Chao; Gu, Chong-Huai; Li, Hong-Jiang; Li, Mi; Liu, Cong; Yang, Jun; Wang, Yang; Wang, Hao-Yu; Qian, Hai-Yan; Geng, Yong-Jian

Hypertension represents one of the most common pre-existing conditions and comorbidities in Coronavirus disease 2019 (COVID-19) patients. To explore whether hypertension serves as a risk factor for disease severity, a multi-centre, retrospective study was conducted in COVID-19 patients. A total of 498 consecutively hospitalised patients with lab-confirmed COVID-19 in China were enrolled in this cohort. Using logistic regression, we assessed the association between hypertension and the likelihood of severe illness with adjustment for confounders. We observed that more than 16% of the enrolled patients exhibited pre-existing hypertension on admission. More severe COVID-19 cases occurred in individuals with hypertension than those without hypertension (21% vs. 10%, P = 0.007). Hypertension associated with the increased risk of severe illness, which was not modified by other demographic factors, such as age, sex, hospital geological location and blood pressure levels on admission. More attention and treatment should be offered to patients with underlying hypertension, who usually are older, have more comorbidities and more susceptible to cardiac complications.