Author: Ivan Mercurio; Vincenzo Tragni; Francesco Busco; Anna De Grassi; Ciro Leonardo Pierri
Title: Protein structure analysis of the interactions between SARS-CoV-2 spike protein and the human ACE2 receptor: from conformational changes to novel neutralizing antibodies Document date: 2020_4_18
ID: mswmkgl4_36
Snippet: RBD from SARS-CoV-1 was crystallized in complex with the FAB domain of two different antibodies, namely m396 (2dd8.pdb, (44) ) and S230 (6nb7.pdb, (45) ). Both of them show high affinity for SARS-CoV-1 spike RBD, being able to block attachment to ACE2 (44, 45) . Nevertheless, they show different peculiarities in their mechanism of action......
Document: RBD from SARS-CoV-1 was crystallized in complex with the FAB domain of two different antibodies, namely m396 (2dd8.pdb, (44) ) and S230 (6nb7.pdb, (45) ). Both of them show high affinity for SARS-CoV-1 spike RBD, being able to block attachment to ACE2 (44, 45) . Nevertheless, they show different peculiarities in their mechanism of action.
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