Author: Ivan Mercurio; Vincenzo Tragni; Francesco Busco; Anna De Grassi; Ciro Leonardo Pierri
Title: Protein structure analysis of the interactions between SARS-CoV-2 spike protein and the human ACE2 receptor: from conformational changes to novel neutralizing antibodies Document date: 2020_4_18
ID: mswmkgl4_5
Snippet: In light of the available cited crystallized/cryo-em solved structures, here we propose a strategy for identifying/drawing new SARS-CoV-2 antibodies directed against the RBD of SARS-CoV-2 that could be used for contrasting SARS-CoV-2 infection, aiming to prevent pre-/post-fusion spike conformation interconversion, responsible for virus invasion, and to provide a molecular structural context for studying new diagnosis kits based on the interaction.....
Document: In light of the available cited crystallized/cryo-em solved structures, here we propose a strategy for identifying/drawing new SARS-CoV-2 antibodies directed against the RBD of SARS-CoV-2 that could be used for contrasting SARS-CoV-2 infection, aiming to prevent pre-/post-fusion spike conformation interconversion, responsible for virus invasion, and to provide a molecular structural context for studying new diagnosis kits based on the interactions between our engineered antibodies and the human SARS-CoV-2 spike RBD.
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