Cervical Dysplasia in a patient with Inherited Epidermodysplasia Verruciformis - A mere co-incidence?

Singh, Amrit P; Jeffus, Susanne K; Shalin, Sara C

Epidermodysplasia verruciformis (EV) is a rare inherited or acquired genodermatosis caused by increased susceptibility to infection by the beta subtypes of human papillomavirus (HPV). The co-occurrence of EV with high-risk (HR) HPV infection leading to cervical dysplasia is unreported in the literature to date. We report a patient with inherited EV who developed extensive anogenital and cervical dysplasia linked to concurrent HR-HPV infection. Literature review suggests that there is a negative correlation of cervical dysplasia and cervical cancer with EV, which suggests that this patient's presentation and course is exceptional. This article is protected by copyright. All rights reserved.