Author: Ivan Mercurio; Vincenzo Tragni; Francesco Busco; Anna De Grassi; Ciro Leonardo Pierri
Title: Protein structure analysis of the interactions between SARS-CoV-2 spike protein and the human ACE2 receptor: from conformational changes to novel neutralizing antibodies Document date: 2020_4_18
ID: mswmkgl4_58
Snippet: The indicated pipeline has allowed to set-up a molecular framework hosting SARS-CoV-2 spike protein, ACE2 receptor and different antibodies in the same pdb session that could be handled with different molecular visualizers. In this molecular framework it is possible to study and predict, at molecular level, interactions between the different "pieces" of the framework that my help in Within the presented molecular framework, we have highlighted a .....
Document: The indicated pipeline has allowed to set-up a molecular framework hosting SARS-CoV-2 spike protein, ACE2 receptor and different antibodies in the same pdb session that could be handled with different molecular visualizers. In this molecular framework it is possible to study and predict, at molecular level, interactions between the different "pieces" of the framework that my help in Within the presented molecular framework, we have highlighted a set of possible efficient interactions between the crystallized m396 antibody and SARS-CoV-2 spike RBD, raising the question about the possibility to test directly m396 on cultured cells exposed to the virus and then, hopefully, on patients.
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