Author: Ke Wang; Wei Chen; Yu-Sen Zhou; Jian-Qi Lian; Zheng Zhang; Peng Du; Li Gong; Yang Zhang; Hong-Yong Cui; Jie-Jie Geng; Bin Wang; Xiu-Xuan Sun; Chun-Fu Wang; Xu Yang; Peng Lin; Yong-Qiang Deng; Ding Wei; Xiang-Min Yang; Yu-Meng Zhu; Kui Zhang; Zhao-Hui Zheng; Jin-Lin Miao; Ting Guo; Ying Shi; Jun Zhang; Ling Fu; Qing-Yi Wang; Huijie Bian; Ping Zhu; Zhi-Nan Chen
Title: SARS-CoV-2 invades host cells via a novel route: CD147-spike protein Document date: 2020_3_14
ID: 5hpbjkft_16
Snippet: It is known that ACE2 has been widely recognized as an essential receptor in virus invasion, and viral replication was specifically inhibited by an anti-ACE2 antibody [21] . However, ACE2 is widely distributed in variety of tissues, especially in the heart, kidney and testes [22] , which plays a profound role in controlling blood pressure, preventing heart failure and kidney injury [23] [24] [25] . For lung diseases, the loss of ACE2 enhances vas.....
Document: It is known that ACE2 has been widely recognized as an essential receptor in virus invasion, and viral replication was specifically inhibited by an anti-ACE2 antibody [21] . However, ACE2 is widely distributed in variety of tissues, especially in the heart, kidney and testes [22] , which plays a profound role in controlling blood pressure, preventing heart failure and kidney injury [23] [24] [25] . For lung diseases, the loss of ACE2 enhances vascular permeability and lung edema, activates the renin-angiotensin system and contributes to pathogenesis of severe lung injury [26] . Therefore, treatment with ACE2 as target may have a negative effect on its protective role.
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