Author: Ke Wang; Wei Chen; Yu-Sen Zhou; Jian-Qi Lian; Zheng Zhang; Peng Du; Li Gong; Yang Zhang; Hong-Yong Cui; Jie-Jie Geng; Bin Wang; Xiu-Xuan Sun; Chun-Fu Wang; Xu Yang; Peng Lin; Yong-Qiang Deng; Ding Wei; Xiang-Min Yang; Yu-Meng Zhu; Kui Zhang; Zhao-Hui Zheng; Jin-Lin Miao; Ting Guo; Ying Shi; Jun Zhang; Ling Fu; Qing-Yi Wang; Huijie Bian; Ping Zhu; Zhi-Nan Chen
Title: SARS-CoV-2 invades host cells via a novel route: CD147-spike protein Document date: 2020_3_14
ID: 5hpbjkft_17
Snippet: In our study, CD147 was identified as a novel receptor of SP, and the CD147-SP interaction facilitated the viral invasion for host cells. As mentioned earlier, CD147 is highly expressed in tumor tissues, inflamed tissues and pathogen infected cells, which leads to low cross-reaction with normal cells [27, 28] . In the meanwhile, Meplazumab, a humanized anti-CD147 antibody, could effectively inhibit the viruses from invading host cells by blocking.....
Document: In our study, CD147 was identified as a novel receptor of SP, and the CD147-SP interaction facilitated the viral invasion for host cells. As mentioned earlier, CD147 is highly expressed in tumor tissues, inflamed tissues and pathogen infected cells, which leads to low cross-reaction with normal cells [27, 28] . In the meanwhile, Meplazumab, a humanized anti-CD147 antibody, could effectively inhibit the viruses from invading host cells by blocking CD147. Our previous research and development of original antibody drugs, such as Metuximab, Metuzumab, Meplazumab, all exhibits sound safety in preclinical research and clinical administration. Therefore, the CD147 targeted drug is safe and reliable in its application, and is a receptor-blocking drug, which blocks the virus from invading host cells, without being affected by virus variation. author/funder. All rights reserved. No reuse allowed without permission.
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