Selected article for: "IFN antagonist and SARS cov"
Author: Kumari G. Lokugamage; Adam Hage; Craig Schindewolf; Ricardo Rajsbaum; Vineet D. Menachery
Title: SARS-CoV-2 is sensitive to type I interferon pretreatment
  • Document date: 2020_3_9
    • ID: 2w0zr9c0_32
    Snippet: Considering the sensitivity to IFN-I, we next sought to evaluate changes between SARS-CoV 148 and SARS-CoV-2 viral proteins. Previous work has established several key IFN antagonist in 149 the SARS-CoV genome including NSP1, NSP3, ORF3b, ORF6, and others (26). Therefore, we 150 . CC-BY-NC 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi......
    Document: Considering the sensitivity to IFN-I, we next sought to evaluate changes between SARS-CoV 148 and SARS-CoV-2 viral proteins. Previous work has established several key IFN antagonist in 149 the SARS-CoV genome including NSP1, NSP3, ORF3b, ORF6, and others (26). Therefore, we 150 . CC-BY-NC 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.07.982264 doi: bioRxiv preprint compared the sequence homology across viral proteins from SARS-CoV, SARS-CoV-2, and 151 several bat SARS-like viruses including WIV16-CoV (27), SHC014-CoV (28), and HKU3.1-CoV 152 (29). Using sequence analysis, we found several changes to SARS-CoV-2 that potentially 153 contribute to its type I IFN sensitivity (Fig. 4) . ORF3b, all five surveyed group 2B CoVs maintain ORF6; however, SARS-CoV-2 had only 69% 171 homology with SARS-CoV while the other three group 2B bat CoVs had >90% conservation. 172

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