Selected article for: "immune response and mammalian immune response innate"

Author: Brandmann, Tobias; Jinek, Martin
Title: Crystal structure of the C-terminal 2’,5’-phosphodiesterase domain of group A rotavirus protein VP3
  • Cord-id: tt0n5d57
  • Document date: 2015_3_25
  • ID: tt0n5d57
    Snippet: In response to viral infections, the mammalian innate immune system induces the production of the second messenger 2’-5’ oligoadenylate (2–5A) to activate latent ribonuclease L (RNase L) that restricts viral replication and promotes apoptosis. A subset of rotaviruses and coronaviruses encode 2’,5’-phosphodiesterase enzymes that hydrolyze 2–5A, thereby inhibiting RNase L activation. We report the crystal structure of the 2’,5’-phosphodiesterase domain of group A rotavirus protein
    Document: In response to viral infections, the mammalian innate immune system induces the production of the second messenger 2’-5’ oligoadenylate (2–5A) to activate latent ribonuclease L (RNase L) that restricts viral replication and promotes apoptosis. A subset of rotaviruses and coronaviruses encode 2’,5’-phosphodiesterase enzymes that hydrolyze 2–5A, thereby inhibiting RNase L activation. We report the crystal structure of the 2’,5’-phosphodiesterase domain of group A rotavirus protein VP3 at 1.39 Å resolution. The structure exhibits a 2H phosphoesterase fold and reveals conserved active site residues, providing insights into the mechanism of 2–5A degradation in viral evasion of host innate immunity.

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