Author: James Bull; Scott L. Nuismer; Rustom Antia
Title: Recombinant vector vaccines and within-host evolution Document date: 2019_2_8
ID: 3vssgben_20
Snippet: In contrast the impairment of vaccine growth depends on the level of immunity (X) and the parameter 263 (k X ). Thus, immunity can develop even when there is little or no impairment, i.e., when k X → 0. Second, 264 adaptive immunity to the vector (Y ) develops according to its own parameter (φ Y ) in response to vaccine 265 plus revertant abundance (X + Y ), and it impairs both vaccine and revertant growth equally by parameter 266 k Y . When r.....
Document: In contrast the impairment of vaccine growth depends on the level of immunity (X) and the parameter 263 (k X ). Thus, immunity can develop even when there is little or no impairment, i.e., when k X → 0. Second, 264 adaptive immunity to the vector (Y ) develops according to its own parameter (φ Y ) in response to vaccine 265 plus revertant abundance (X + Y ), and it impairs both vaccine and revertant growth equally by parameter 266 k Y . When revertant is present, it will increase the level of immunity to vector backbone/revertant but not 267 directly affect immunity specific to the vaccine. This immunity will result in faster clearance of both revertant 268 and vaccine, and this results in decreased immunity to the antigen.
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