Selected article for: "civet human and human civet"
Author: Juan Angel Patino-Galindo; Ioan Filip; Mohammed AlQuraishi; Raul Rabadan
Title: Recombination and lineage-specific mutations led to the emergence of SARS-CoV-2
  • Document date: 2020_2_18
    • ID: bgdcm1i1_21
    Snippet: In this work, we have analyzed the evolution of SARS-CoV-2 and its closest relatives. We suggest a twohit scenario involving both ancestral recombination and recent mutational events in the lineage that led to SARS-CoV-2. It has been hypothesized previously that recombination 8,24 and rapid evolution was observed between bat, civet and human SARS-CoVs 19 . We show that the recombination events preferentially affect the RBD region in the Spike gen.....
    Document: In this work, we have analyzed the evolution of SARS-CoV-2 and its closest relatives. We suggest a twohit scenario involving both ancestral recombination and recent mutational events in the lineage that led to SARS-CoV-2. It has been hypothesized previously that recombination 8,24 and rapid evolution was observed between bat, civet and human SARS-CoVs 19 . We show that the recombination events preferentially affect the RBD region in the Spike gene, both at the order of genus (betacoronavirus) and In conclusion, our evolutionary analyses have revealed that the evolutionary processes leading to SARS-CoV-2 can be explained by a two-hit scenario of recombination and recent mutational events in the Spike.

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