Selected article for: "detection sensitivity and RT PCR analysis"
Author: Anne Louise Wyllie; John Fournier; Arnau Casanovas-Massana; Melissa Campbell; Maria Tokuyama; Pavithra Vijayakumar; Bertie Geng; M. Catherine Muenker; Adam J. Moore; Chantal B. F. Vogels; Mary E. Petrone; Isabel M. Ott; Peiwen Lu; Alice Lu-Culligan; Jonathan Klein; Arvind Venkataraman; Rebecca Earnest; Michael Simonov; Rupak Datta; Ryan Handoko; Nida Naushad; Lorenzo R. Sewanan; Jordan Valdez; Elizabeth B. White; Sarah Lapidus; Chaney C. Kalinich; Xiaodong Jiang; Daniel J. Kim; Eriko Kudo; Melissa Linehan; Tianyang Mao; Miyu Moriyama; Ji Eun Oh; Annsea Park; Julio Silva; Eric Song; Takehiro Takahashi; Manabu Taura; Orr-El Weizman; Patrick Wong; Yexin Yang; Santos Bermejo; Camila Odio; Saad B. Omer; Charles S. Dela Cruz; Shelli Farhadian; Richard A. Martinello; Akiko Iwasaki; Nathan D. Grubaugh; Albert I. Ko
Title: Saliva is more sensitive for SARS-CoV-2 detection in COVID-19 patients than nasopharyngeal swabs
  • Document date: 2020_4_22
    • ID: lt7qsxxh_2
    Snippet: Saliva sampling is an appealing alternative to nasopharyngeal swab, since collecting saliva is non-invasive and easy to self-administer. An analysis of nasopharyngeal and saliva concordance for RT-PCR detection of respiratory pathogens, including two seasonal human coronaviruses, suggests comparable diagnostic sensitivity between the two sample types 10, 11 . Preliminary findings indicate that ( 1 ) SARS-CoV-2 can be detected from the saliva of C.....
    Document: Saliva sampling is an appealing alternative to nasopharyngeal swab, since collecting saliva is non-invasive and easy to self-administer. An analysis of nasopharyngeal and saliva concordance for RT-PCR detection of respiratory pathogens, including two seasonal human coronaviruses, suggests comparable diagnostic sensitivity between the two sample types 10, 11 . Preliminary findings indicate that ( 1 ) SARS-CoV-2 can be detected from the saliva of COVID-19 patients 12 and ( 2 ) self-collected saliva samples have comparable SARS-CoV-2 detection sensitivity to nasopharyngeal swabs collected by healthcare workers from mild and subclinical COVID-19 cases 13 . Critically, however, no rigorous evaluation of the sensitivity of SARS-CoV-2 detection in saliva with respect to nasopharyngeal swabs has been conducted from inpatients during the course of COVID-19 infection.

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