Author: Ozsurekci, Yasemin; Aykac, Kubra; Er, Ahmet Gorkem; Halacli, Burcin; Arasli, Mehmet; Oygar, Pembe Derin; Gürlevik, Sibel; Cura Yayla, Burcu Ceylan; Karakaya, Jale; Alp, Alparslan; Topeli, Arzu; Cengiz, Ali Bülent; Akova, Murat; Ceyhan, Mehmet
Title: Predictive value of cytokine/chemokine responses for the disease severity and management in children and adult cases with COVIDâ€19 Cord-id: yqg0la69 Document date: 2020_12_1
ID: yqg0la69
Snippet: The disease course of children with coronavirus disease 2019 (COVIDâ€19) seems milder as compared with adults, however, actual reason of the pathogenesis still remains unclear. There is a growing interest on possible relationship between pathogenicity or disease severity and biomarkers including cytokines or chemokines. We wondered whether these biomarkers could be used for the prediction of the prognosis of COVIDâ€19 and improving our understanding on the variations between pediatric and adul
Document: The disease course of children with coronavirus disease 2019 (COVIDâ€19) seems milder as compared with adults, however, actual reason of the pathogenesis still remains unclear. There is a growing interest on possible relationship between pathogenicity or disease severity and biomarkers including cytokines or chemokines. We wondered whether these biomarkers could be used for the prediction of the prognosis of COVIDâ€19 and improving our understanding on the variations between pediatric and adult cases with COVIDâ€19. The acute phase serum levels of 25 cytokines and chemokines in the serum samples from 60 COVIDâ€19 pediatric (n = 30) and adult cases (n = 30) including 20 severe or critically ill, 25 moderate and 15 mild patients and 30 healthy pediatric (n = 15) and adult (n = 15) volunteers were measured using commercially available fluorescent bead immunoassay and analyzed in combination with clinical data. Interferon gammaâ€induced protein 10 (IPâ€10) and macrophage inflammatory protein (MIP)−3β levels were significantly higher in patient cohort including pediatric and adult cases with COVIDâ€19 when compared with all healthy volunteers (p ≤ .001 in each) and whereas IPâ€10 levels were significantly higher in both pediatric and adult cases with severe disease course, MIPâ€3β were significantly lower in healthy controls. Additionally, IPâ€10 is an independent predictor for disease severity, particularly in children and interleukinâ€6 seems a relatively good predictor for disease severity in adults. IPâ€10 and MIPâ€3β seem good research candidates to understand severity of COVIDâ€19 in both pediatric and adult population and to investigate possible pathophysiological mechanism of COVIDâ€19.
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