Author: Lu Li; Shuang Li; Manman Xu; Pengfei Yu; Sujun Zheng; Zhongping Duan; Jing Liu; Yu Chen; Junfeng Li
Title: Risk factors related to hepatic injury in patients with corona virus disease 2019 Document date: 2020_3_3
ID: 73gxq2w6_23
Snippet: As the number of patients with COVID-19 continues to rise, liver injury is frequently reported as extra-pulmonary clinical feature. Some recent studies revealed that nearly a half of patients experienced different degrees of liver injury 7.8 . However, as far as we know, there is no study on the factors of liver injury. Such as SARS, SARS-CoV-2 uses the same cell entry receptor angiotensin converting enzyme-II 4 , which is expressed in the liver .....
Document: As the number of patients with COVID-19 continues to rise, liver injury is frequently reported as extra-pulmonary clinical feature. Some recent studies revealed that nearly a half of patients experienced different degrees of liver injury 7.8 . However, as far as we know, there is no study on the factors of liver injury. Such as SARS, SARS-CoV-2 uses the same cell entry receptor angiotensin converting enzyme-II 4 , which is expressed in the liver tissue as well. A lately research showed that bile duct cells had higher specific expression of angiotensin converting enzyme-II than hepatocytes 12 , which indicated the possibility of SARS-CoV-2 infected bile duct cells directly and caused hepatic injury. It's suggested that bile duct epithelial cells may play a key role in immunoreaction. However, clinical data from two researches showed that the bile duct injury related indexes alkaline phosphatase, gamma-glutamyl transpeptidase and total bilirubin did not increase significantly 10, 14 .
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