Outcomes and Prognostic Factors in a Large Cohort of Hospitalized Cancer Patients With COVID-19

Nader Marta, Guilherme; Colombo Bonadio, Renata; Nicole Encinas Sejas, Odeli; Watarai, Gabriel; Mathias Machado, Maria Cecilia; Teixeira Frasson, Lorena; Motta Venchiarutti Moniz, Camila; de Luca Ito, Raquel Keiko; Peixoto, Driele; Oliveira Hoff, Camilla; Menegatti Anastacio, Veruska; Ribeiro, Ulysses; Pereira, Juliana; Rocha, Vanderson; Abdala, Edson; Del Pilar Estevez-Diz, Maria; Hoff, Paulo M.

Patients with cancer are at increased risk for unfavorable outcomes from COVID-19. Knowledge about the outcome determinants of severe acute respiratory syndrome coronavirus 2 infection in this population is essential for risk stratification and definition of appropriate management. Our objective was to evaluate prognostic factors for all-cause mortality in patients diagnosed with both cancer and COVID-19. METHODS: All consecutive patients with cancer hospitalized at our institution with COVID-19 were included. Electronic medical records were reviewed for clinical and laboratory characteristics potentially associated with outcomes. RESULTS: Five hundred seventy-six consecutive patients with cancer and COVID-19 were included in the present study. An overall in-hospital mortality rate of 49.3% was demonstrated. Clinical factors associated with increased risk of death because of COVID-19 were age over 65 years, Eastern Cooperative Oncology Group performance status > 0 zero, best supportive care, primary lung cancer, and the presence of lung metastases. Laboratory findings associated with a higher risk of unfavorable outcomes were neutrophilia, lymphopenia, and elevated levels of D-dimer, creatinine, C-reactive protein, or AST. CONCLUSION: A high mortality rate in patients with cancer who were diagnosed with COVID-19 was demonstrated in the present study, emphasizing the need for close surveillance in this group of patients, especially in those with unfavorable prognostic characteristics.