Selected article for: "assay validation and false positive"
Author: NISREEN M.A. OKBA; Marcel A Muller; Wentao Li; Chunyan Wang; Corine H. GeurtsvanKessel; Victor M. Corman; Mart M. Lamers; Reina S. Sikkema; Erwin de Bruin; Felicity D. Chandler; Yazdan Yazdanpanah; Quentin Le Hingrat; Diane Descamps; Nadhira Houhou-Fidouh; Chantal B. E. M. Reusken; Berend-Jan Bosch; Christian Drosten; Marion P.G. Koopmans; Bart L. Haagmans
Title: SARS-CoV-2 specific antibody responses in COVID-19 patients
  • Document date: 2020_3_20
    • ID: 9595vm0k_4
    Snippet: Serum samples were collected from PCR-confirmed mild and severe COVID-19 patients ( Table 1 ) from France in accordance with the local ethical approvals. Samples used for assay validation were from persons PCR-diagnosed infections with of human coronaviruses (HCoV-229E, NL63 or OC43), SARS, MERS, or with a range of other respiratory viruses ( Table 1) as published previously (6) . Samples from patients with recent CMV, EBV or mycoplasma pneumon.....
    Document: Serum samples were collected from PCR-confirmed mild and severe COVID-19 patients ( Table 1 ) from France in accordance with the local ethical approvals. Samples used for assay validation were from persons PCR-diagnosed infections with of human coronaviruses (HCoV-229E, NL63 or OC43), SARS, MERS, or with a range of other respiratory viruses ( Table 1) as published previously (6) . Samples from patients with recent CMV, EBV or mycoplasma pneumoniae infection were included as these have a higher likelihood of causing false positive results. We used serum samples from 45 healthy blood donors (Cohort A) as negative controls; Sanquin Blood Bank (Rotterdam, the Netherlands) obtained written informed consent for research use.

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