Susceptibility of the patients infected with Sars-Cov2 to oxidative stress and possible interplay with severity of the disease

Gadotti, Ana C.; Lipinski, Anna L.; Vasconcellos, Franciane TF.; Marqueze, Luis F.; Cunha, Eduardo BB.; Campos, Amanda C.; Oliveira, Camila F.; Amaral, Andréa NM.; Baena, Cristina P.; Telles, João P.; Tuon, Felipe F.; Pinho, Ricardo A.

Several recent reviews have suggested a role of oxidative stress in the pathophysiology of COVID-19, but its interplay with disease severity has not been revealed yet. In the present study, we aimed to investigate the association between the severity of COVID‐19 and oxidative stress parameters. Clinical data of 77 patients with COVID‐19 admitted to the hospital were analyzed and divided into moderate (n = 44) and severe (n = 33) groups based on their clinical condition. Production of oxidant (hydrogen peroxide) and defense antioxidants (total antioxidant capacity, reduced and oxidized glutathione, glutathione s-transferase), and oxidative damage (malondialdehyde, carbonyl, and sulfhydryl) were assessed using the serum samples. The results revealed that severe patients who presented high serum leukocyte count and CRP level stayed for a longer period in the hospital. However, there was no correlation observed between the oxidative stress parameters and degree of COVID-19 severity in the present study. In conclusion, these results indicate that the disease severity may not be a detrimental factor contributing to the changes in the redox profile of hospitalized patients with COVID-19.