Selected article for: "human body and nervous system"
Author: Kang Zhao; Jucun Huang; Dan Dai; Yuwei Feng; Liming Liu; Shuke Nie
Title: Acute myelitis after SARS-CoV-2 infection: a case report.
  • Document date: 2020_3_18
    • ID: ksbha7kz_8
    Snippet: Our study firstly reported a post-infectious myelitis case in the world, indicating acute myelitis might be the neurological complication of 2019-nCov. It had been demonstrated that microbes including mycoplasma pneumoniae, EBV, CMV, rhinovirus and measles were implicated in postinfectious acute myelitis [11] [12] [13] . Mycoplasma pneumoniae was thought to be one of the most recognized infections. Probable hypothesis was that infectious organism.....
    Document: Our study firstly reported a post-infectious myelitis case in the world, indicating acute myelitis might be the neurological complication of 2019-nCov. It had been demonstrated that microbes including mycoplasma pneumoniae, EBV, CMV, rhinovirus and measles were implicated in postinfectious acute myelitis [11] [12] [13] . Mycoplasma pneumoniae was thought to be one of the most recognized infections. Probable hypothesis was that infectious organism was targeted against by immunologic system which also attacked central nervous system (CNS) tissue because of structural similarities between the microbial cellular wall components and neuronal receptors 14 . In this study, the IgM antibody of common infectious organisms including mycoplasma pneumoniae, EBV and CMV were negative, and the symptoms of acute myelitis occurred after high fever and diagnosis of COVID-19, suggesting 2019-nCov might be the pathogenic virus. Moreover, recent study showed that SARS-CoV-2 could enter the human body through ACE2 receptors on the surface of human cells and causes disease 5 . It was intriguing that ACE2 receptors were also expressed on the membrane of spinal cord neurons 9, 10 , furtherly suggesting that SARS-CoV-2 was implicated in acute myelitis by the specific ACE2 receptors on the surface of spinal cord neurons.

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