Selected article for: "loop stem element and RNA structure"
Author: Ramya Rangan; Ivan N. Zheludev; Rhiju Das
Title: RNA genome conservation and secondary structure in SARS-CoV-2 and SARS-related viruses
  • Document date: 2020_3_28
    • ID: kjeqdse5_26
    Snippet: The secondary structures predicted here present a reasonable starting point for 3D modeling of RNA-only structures in various regions, including the 5´ UTR stem loop 5, the frame-shifting element, the 3´ UTR pseudoknot, and the 3´ stem-loop II-like motif. Furthermore, these regions and novel predicted structures can serve as candidates for RNA-only structure determination. Such 3D structures have the potential to reveal well-defined 3D folds w.....
    Document: The secondary structures predicted here present a reasonable starting point for 3D modeling of RNA-only structures in various regions, including the 5´ UTR stem loop 5, the frame-shifting element, the 3´ UTR pseudoknot, and the 3´ stem-loop II-like motif. Furthermore, these regions and novel predicted structures can serve as candidates for RNA-only structure determination. Such 3D structures have the potential to reveal well-defined 3D folds with conserved binding domains for small-molecule drugs, potentially presenting alternative approaches for targeting SARS-CoV-2.

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