Author: Nila Roy Choudhury; Gregory Heikel; Maryia Trubitsyna; Peter Kubik; Jakub Stanislaw Nowak; Shaun Webb; Sander Granneman; Christos Spanos; Juri Rappsilber; Alfredo Castello; Gracjan Michlewski
Title: RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination Document date: 2017_10_9
ID: ifla4aix_54
Snippet: Previously, the CC domain of TRIM25 has been implicated in binding to RNA (Kwon et al., 2013) . TRIM25 deletion mutants lacking the CC domain were unable to interact with RNA in the UV immunoprecipitation and T4 polynucleotide kinase assays (Kwon et al., 2013) . In contrast, the mutant lacking the PRY/SPRY domain still retained RNA-binding ability......
Document: Previously, the CC domain of TRIM25 has been implicated in binding to RNA (Kwon et al., 2013) . TRIM25 deletion mutants lacking the CC domain were unable to interact with RNA in the UV immunoprecipitation and T4 polynucleotide kinase assays (Kwon et al., 2013) . In contrast, the mutant lacking the PRY/SPRY domain still retained RNA-binding ability.
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